Neutralism versus selectionism: Chargaff's second parity rule, revisited
نویسندگان
چکیده
منابع مشابه
REVIEW Selectionism and Neutralism in Molecular Evolution
Charles Darwin proposed that evolution occurs primarily by natural selection, but this view has been controversial from the beginning. Two of the major opposing views have been mutationism and neutralism. Early molecular studies suggested that most amino acid substitutions in proteins are neutral or nearly neutral and the functional change of proteins occurs by a few key amino acid substitution...
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There is a general view that instructionist and selectionist theories of adapting to an environment are mutually incompatible [1-4]. Below, we report the results of a series of computer simulations that demonstrate that this is not necessarily the case. Our simulations show that the main ideas of selectionism can be incorporated into a standard instructionist framework, which can benefit both p...
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متن کاملMismatch Repair Error Implies Chargaff's Second Parity Rule
Chargaff’s second parity rule (PR2) holds empirically for most types of DNA that along single strands of DNA the base contents are equal for complimentary bases, A = T,G = C. A Markov chain model is constructed to track the evolution of any single base position on a given single strand of DNA whose organism is equipped with the process of mismatch repair. Under the key assumptions that the mism...
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ژورنال
عنوان ژورنال: Genetica
سال: 2021
ISSN: 0016-6707,1573-6857
DOI: 10.1007/s10709-021-00119-5